Multi-frequency low-dose intravenous iron on oxidative stress in maintenance hemodialysis patients.
10.3969/j.issn.1672-7347.2012.08.015
- Author:
Li YIN
1
;
Xing CHEN
;
Junxiang CHEN
;
Meichu CHENG
;
Youming PENG
;
Lijun YANG
Author Information
1. Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Anemia;
drug therapy;
etiology;
Female;
Ferric Compounds;
administration & dosage;
Ferric Oxide, Saccharated;
Glucaric Acid;
Humans;
Injections, Intravenous;
Kidney Failure, Chronic;
complications;
drug therapy;
Male;
Middle Aged;
Oxidative Stress;
drug effects;
Renal Dialysis;
Sucrose;
administration & dosage;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2012;37(8):844-848
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of different intravenous iron treatment regimens on anemia and oxidative stress in maintenance hemodialysis (MHD) patients.
METHODS:A total of 58 MHD patients were randomly divided into a multi-frequency low-dose intravenous iron group (iron sucrose 25 mg, twice a week for 8 weeks, n=19), a less-frequency regular-dose intravenous iron group (iron sucrose 100 mg, once every two weeks for 8 weeks, n=19), and a non-iron group (n=20). Another 20 healthy people served as a control group (n=20). The changes of hemoglobin (Hb), hematocrit (HCT), serum ferritin (SF) and transferrin saturation (TSAT), as well as the oxidative stress parameters of malon-dialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were detected before and after the treatment.
RESULTS:After 8 weeks, compared with the non-iron group, the levels of Hb, HCT, SF and TSAT in the two iron groups were significantly elevated (P<0.01), but there was no difference between the two iron groups (P>0.05). After the single dialysis, the two iron groups had higher level of serum MDA, MPO and lower level of serum SOD than that of the non-iron supplementation group (P<0.01). The multi-frequency low-dose intravenous iron group had lower level of serum MDA [(5.37 ± 0.73) nmol/mL vs (6.37±1.67) nmol/mL], MPO [(81.41±7.60) U/L vs (96.75±16.97) U/L] and higher level of serum SOD [(84.77 ± 14.02) U/mL vs (68.23 ± 4.90) U/mL] than that of the less-frequency regular-dose intravenous iron group. After 8 weeks, there was no significant difference between the two iron groups (P>0.05).
CONCLUSION:Multi-frequency low-dose intravenous iron can effectively improve anemia in MHD patients, whose acute oxidative stress is lower than that of less-frequency regular-dose intravenous iron, and is a relatively safe and effective intravenous iron treatment regimen.