Vibration perception threshold in diagnosing diabetic peripheral neuropathy by receiver operating characteristic curve.
- Author:
Yu HOU
1
;
Sha LIU
;
Tingting ZHU
;
Huan ZHANG
;
Gang LIU
;
Yan ZHU
;
Huiling CHEN
Author Information
1. Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Diabetes Mellitus, Type 2;
complications;
Diabetic Neuropathies;
diagnosis;
Female;
Humans;
Male;
Middle Aged;
Neural Conduction;
physiology;
Perception;
Peripheral Nervous System Diseases;
diagnosis;
ROC Curve;
Sensory Thresholds;
physiology;
Vibration
- From:
Journal of Central South University(Medical Sciences)
2012;37(9):951-956
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the diagnostic value of vibration perception threshold (VPT) in diabetic peripheral neuropathy (DPN) by the receiver operating characteristic curve (ROC) and to establish its cut-off threshold.
METHODS:All patients had the VPT examination and nerve conduction velocity (NCV) examination. NCV examination showed that 283 patients with Type 2 diabetes were divided into a DPN group (n=151) and an NDPN group (n=132). The VPT diagnosis was evaluated by Youden index, sensitivity, specificity and the area under ROC curve. The best cut-off threshold was defined by the Youden index.
RESULTS:1) The NCV was significantly slower, while the VPT was higher in the DPN group than those in the NDPN group (both P values <0.05). 2) The VPT and NCV of both sides of the limb had no difference in all patients. 3) With NCV as the golden diagnosis criterion, the area under ROC of VPT was 0.707, the best cut-off threshold was 10.54 V, the sensitivity was 0.596, the specificity was 0.848, and the Youden index was 0.445. 4) The diagnosis ratio of NCV combined with VPT was 60.4%, significantly higher than that of NCV alone (P<0.05).
CONCLUSION:Compared with NCV examination, VPT has good diagnostic value for DPN. The best cut-off value is 10.54 V.
