Expression of ADAMTS-2 and TGF-β1 in cirrhotic liver.
10.3969/j.issn.1672-7347.2012.10.010
- Author:
Hanjun LI
1
;
Chao DONG
;
Tingjia CAO
;
Shi CHANG
Author Information
1. Department of General Surgery, Wuhan General Hospital of Guangzhou Military, Wuhan, China.
- Publication Type:Journal Article
- MeSH:
ADAM Proteins;
metabolism;
ADAMTS Proteins;
ADAMTS4 Protein;
Blotting, Western;
Humans;
Immunohistochemistry;
Liver;
metabolism;
pathology;
Liver Cirrhosis;
metabolism;
Procollagen N-Endopeptidase;
metabolism;
Transforming Growth Factor beta1;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2012;37(10):1026-1030
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the expression and distribution of a disintegrin and metalloprotease with thrombospondin motif (ADAMTS)-2 and transforming growth factor (TGF) -β1 in patients with or without cirrhosis, and to determine their relation.
METHODS:The liver tissues from 16 patients with cirrhotic portal hypertensive and 8 patients with liver injury were collected in Wuhan General Hospital from March to June, 2010. Immunohistochemistry and Western blot were applied to detect the protein expression of ADAMTS-2 and TGF-β1.
RESULTS:Immunohistochemistry showed that the expression of ADAMTS-2 and TGF-β1 was significantly higher in the cirrhotic tissues than that in normal tissues (P<0.05). Western blot also showed the expression of ADAMTS-2 and TGF-β1 in the cirrhosis tissues was significantly higher than that in normal tissues (P<0.05). There was a positive correlation between ADAMTS-2 and TGF-β1 (r=0.862, P<0.01).
CONCLUSION:ADAMTS-2 and TGF-β1 may have a synergistic reaction in promoting liver cirrhosis.
