Concomitant Drug Reaction with Eosinophilia and Systemic Symptom Syndrome from Ethambutol and Autoimmune Hepatitis from Isoniazid.
10.4166/kjg.2016.67.5.267
- Author:
Joon Hyuk CHOI
1
;
Nae Yun HEO
;
Seung Ha PARK
;
Chan Sun PARK
;
Kyeong Min JO
;
Woo Gyeong KIM
;
Kyung Han NAM
Author Information
1. Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. nyheo@hanmail.net
- Publication Type:Case Report
- Keywords:
Drug hypersensitivity syndrome;
Hepatitis, autoimmune;
Antitubercular agents
- MeSH:
Antitubercular Agents;
Drug Hypersensitivity Syndrome;
Eosinophilia*;
Ethambutol*;
Hepatitis;
Hepatitis, Autoimmune*;
Isoniazid*
- From:The Korean Journal of Gastroenterology
2016;67(5):267-271
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Anti-tuberculosis drugs can produce levels of hepatotoxicity ranging from mild elevation of aminotransferase to severe acute hepatitis. A few cases of drug-induced autoimmune hepatitis or the drug reaction with eosinophilia and systemic symptom (DRESS) syndrome by anti-tuberculosis medications have been reported. However, concomitant occurrence of these two disorders has not been reported. Here, we present a case of severe acute hepatitis with DRESS syndrome and autoimmune hepatitis resulting from primary standard anti-tuberculosis drugs. Both conditions were successfully treated with a systemic steroid regimen.
