High ligation of varicocele improves sperm DNA integrity in patients with asthenospermia.
10.3969/j.issn.1672-7347.2012.12.008
- Author:
Yingjun WANG
1
;
Weili ZHANG
;
Dawen LI
Author Information
1. Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Asthenozoospermia;
etiology;
surgery;
DNA Damage;
DNA Fragmentation;
Humans;
Ligation;
Male;
Middle Aged;
Semen;
Spermatic Cord;
blood supply;
surgery;
Spermatozoa;
pathology;
Urologic Surgical Procedures, Male;
Varicocele;
complications;
surgery;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2012;37(12):1228-1232
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To assess how high ligation of varicocele improves sperm DNA integrity in patients with asthenospermia.
METHODS:The DNA fragmentation index (DFI) and semen analysis were conducted in 30 subjects with normal sperm samples, and the parameters were used as references. Fifty-six patients from the Department of Urology of the Second Affiliated Hospital of Chongqing Medical University from April 2009 to April 2011 all signed the informed consent. Semen was collected 1 week before the high ligation of varicocele and 3 months after the surgery. We compared the change of the integrity of sperm DNA and semen.
RESULTS:Three months after the high ligation of varicocele, DFI and semen indexes significantly improved (P<0.05), but no significant difference was found between open surgery and laparoscopic surgery, unilateral varicocele and bilateral varicocele and Grade I, Grade II, Grade III varicocele (P>0.05). Six months later, 27 spouses were pregnant out of the 53 surgical patients (50.9%). DFI of the pregnancy group and the non-pregnancy group was (13.90±9.70)% and (20.10±10.27)%, with significant different (P<0.05).
CONCLUSION:Varicocelectomy can improve the sperm DNA integrity in patients with asthenospermia, whose effect is not related to surgical approach, unilateral or bilateral varicocele or varicocele grade.
