Serum retinol binding protein 4 and bone metabolism in patients with type 2 diabetes.
10.3969/j.issn.1672-7347.2012.02.015
- Author:
Ailing YE
1
;
Hong ZHANG
;
Yiqun PENG
;
Eryuan LIAO
Author Information
1. Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Bone Density;
Bone and Bones;
metabolism;
Collagen Type I;
blood;
Cross-Sectional Studies;
Diabetes Mellitus, Type 2;
blood;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Osteocalcin;
blood;
Peptides;
blood;
Retinol-Binding Proteins, Plasma;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2012;37(2):197-202
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the relation between serum concentration of retinol binding protein (RBP) 4 and markers of bone metabolism, bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).
METHODS:A total of 82 patients newly diagnosed with T2DM and 46 subjects with normal glucose tolerance (NGT) enrolled in the cross-sectional study. Subset analyses were performed, dividing subjects on the basis of gender into M-T2DM, F-T2DM, M-NGT, and F-NGT. The serum concentrions of RBP4, osteocalcin (OC) and C-terminal telopeptide of collagen type I (CTX) were measured with ELISA. The BMD was measured by dual-energy X-ray absorptiometry (DXA) with a Hologic QDR4500A device.
RESULTS:In both the T2DM groups, lnRBP4 showed a positive relationship with lnCTX (M-T2DM, r=0.564, P<0.01; F-T2DM, r=0.386, P=0.018), but no association with lnOC. After adjusting for age, smoking, creatinine clearance rate (CCr), and waist-to-hip ratio (WHR), lnRBP4 still showed a strong association with lnCTX in the M-T2DM group (r'=0.536, P<0.01), but not in F-T2DM (r'=0.317, P=0.072). In the NGT group, there was no relation between lnRBP4 and lnCTX or lnOC. LnRBP4 showed no association with BMD in all groups.
CONCLUSION:The level of serum RBP4 may be correlated with the bone metabolism in patients with T2DM.
