Study on the distribution of buprenorphione in the bodies of the rabbits.
10.3969/j.issn.1672-7347.2012.03.015
- Author:
Dongxian LIU
1
;
Jiangnan HE
Author Information
1. Department of Criminal Technology, Hunan Police Academy, Changsha 410138, China. liudongxian@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Analgesics, Opioid;
pharmacokinetics;
Animals;
Buprenorphine;
pharmacokinetics;
urine;
Female;
Male;
Rabbits;
Tissue Distribution
- From:
Journal of Central South University(Medical Sciences)
2012;37(3):296-299
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the distribution of buprenorphione in the bodies of rabbits.
METHODS:Buprenorphione was administrated to rabbits orally or by intravenous injection (0.04 mg/kg buprenorphione). Two hours after administration, rabbits were killed and their blood, urine, liver, kidney, lung, stomach, brain, heart, stomach content and feces were collected. The concentrations of buprenorphione in these body fluids and tissues were determined by liquid chromatography-mass spectrometry (LC-MS).
RESULTS:The results show the distribution of buprenorphione in rabbit's body: urine>stomach content>brain >heart >stomach>lung> kidney > liver > blood> feces.
CONCLUSION:The method developed can be used for the detection of buprenorphione in biological fluids and tissues in forensic practice. Urine is the preferred sample for screening for buprenorphione abuse.
