Prevalence of laboratory aspirin resistance in 431 old patients.
10.3969/j.issn.1672-7347.2012.04.003
- Author:
Xiaoli LI
1
;
Li FAN
;
Jian CAO
;
Qiang WANG
;
Lin LIU
;
Guoliang HU
;
Yixin HU
;
Yazhen WANG
;
Ruojun WU
Author Information
1. First Department of Geriatric Cardiology of South Building, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Aspirin;
pharmacology;
therapeutic use;
Cerebrovascular Disorders;
blood;
drug therapy;
Coronary Disease;
blood;
drug therapy;
Drug Resistance;
Female;
Humans;
Male;
Platelet Aggregation;
drug effects;
Platelet Aggregation Inhibitors;
pharmacology;
therapeutic use;
Prevalence;
Surveys and Questionnaires
- From:
Journal of Central South University(Medical Sciences)
2012;37(4):338-342
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate correlation between and agreement in light transmittance aggregation (LTA) and thromboelastography (TEG) in laboratory diagnosing aspirin resistance (AR), and to determine the prevalence of AR in old patients.
METHODS:Patients in the Wanshoulu District of Beijing with ischemic atherothrombotic diseases were recruited. Inclusion criteria were age ≥ 65 years, and having received regular aspirin therapy (75-100 mg daily) for at least 4 weeks. On the basis of LTA assay, the definition of AR was taken as aggregation of ≥ 20% with AA (arachidonic acid), and of ≥ 70% with ADP (adenosine diphosphate). Aspirin-sensitivity was indicated by the absence of either of these criteria; aspirinsensitivity was indicated as both criteria being met. The definition of AR by TEG is ≥ 50% via AA-induced whole blood aggregation.
RESULTS:There were 13.69% prevalence of aspirin resistance for LTA using AA as the agonist, 30.16% prevalence of aspirin resistance for LTA using ADP as the agonist, and 23.67% prevalence of aspirin resistance for TEG using AA as the agonist. Results from these tests showed poor agreement (Kappa<0.4). However, by the method of LTA using AA and ADP as the agonists, prevalence of AR was 8.35%. By methods of AA-induced LTA and AA-induced TEG, prevalence of AR was 8.82%. Results from these two latter methods showed good agreement (Kappa = 0.793).
CONCLUSION:Combined methods, as described here, have good correlation and agreement in the assays of AR, and the results with them represent a realistic measure of the prevalence of AR. Prevalence of AR of elderly patients from Wanshoulu district of Beijing is about 9%.
