Differential expression of DJ-1 and HSP27 in invasive and non-invasive pituitary adenomas.
10.3969/j.issn.1672-7347.2012.05.009
- Author:
Wei CHEN
1
;
Xiaofeng SHI
;
Yunsheng LIU
;
Cui LI
;
Zhiqiang XIAO
;
Zhixiong LIU
Author Information
1. Department of Neurosurgery, Longgang Central Hospital of Shenzhen, Shenzhen, China.
- Publication Type:Journal Article
- MeSH:
Adenoma;
metabolism;
pathology;
Adult;
Biomarkers, Tumor;
metabolism;
Female;
Gene Expression Regulation, Neoplastic;
HSP27 Heat-Shock Proteins;
genetics;
metabolism;
Humans;
Intracellular Signaling Peptides and Proteins;
genetics;
metabolism;
Male;
Middle Aged;
Neoplasm Invasiveness;
Oncogene Proteins;
genetics;
metabolism;
Pituitary Neoplasms;
metabolism;
pathology;
Protein Deglycase DJ-1;
Signal Transduction;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2012;37(5):481-484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore whether oncogenes DJ-1 and HSP27 are associated with invasiveness of human pituitary adenoma.
METHODS:Total proteins were extracted from samples of 20 invasive and 20 non-invasive pituitary adenomas and the expression of DJ-1 and HSP27 was analyzed by Western blot. The correlation of DJ-1and HSP27 with the invasiveness of pituitary adenoma was analyzed.
RESULTS:The strong positive rates of DJ-1 and HSP27 in the 20 invasive pituitary adenoma were 70% (14/20) and 80% (16/20), respectively. The invasive group had significantly higher expression of DJ-1 and HSP27 proteins than the noninvasive group [10% (2/20), 10% (2/20), respectively]. There was a positive correlation between the expression of DJ-1, HSP27 proteins and the invasiveness of pituitary adenoma as judged by the Spearman rank correlation test (P<0.05).
CONCLUSION:The proliferative activity and abnormal expression of oncogenes DJ-1 and HSP27 may play a significant role in tumorigenesis and progression of pituitary adenoma. There was a significant correlation between the expression of DJ-1 and HSP27 and the invasiveness of pituitary adenoma.
