Comparison of endoscopic band ligation and propranolol for the primary prophylaxis of variceal bleeding in cirrhosis.
10.3969/j.issn.1672-7347.2012.05.016
- Author:
Chao FENG
1
;
Feizhou HUANG
;
Wanpin NIE
;
Xunyang LIU
;
Shuping REN
Author Information
1. Department of General Surgery, Central South University, Changsha, China. fccc.1234@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Aged;
Endoscopy, Gastrointestinal;
methods;
Esophageal and Gastric Varices;
complications;
drug therapy;
surgery;
therapy;
Female;
Gastrointestinal Hemorrhage;
etiology;
prevention & control;
Humans;
Ligation;
methods;
Liver Cirrhosis;
complications;
Male;
Middle Aged;
Propranolol;
therapeutic use
- From:
Journal of Central South University(Medical Sciences)
2012;37(5):513-516
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare endoscopic variceal ligation (EVL) with propranolol for prophylaxis of first variceal bleeding.
METHODS:We chose 168 patients with cirrhosis and esophageal varices in our hospital and allocated them to EVL and propranolol groups. Treatment effectiveness and safety in the 2 groups were observed.
RESULTS:he parameters of two groups were similar before therapy. Follow-up period was 8-36 months. Variceal bleeding occurred in 24 (28.6%) of the EVL group and in 20 (23.9%) of the propranolol group (P>0.05). Overall mortality and death related to bleeding were similar (21.4% vs 17.9%; 7.1% vs 6.0%, P>0.05). Adverse events related to EVL were 43 (3 of them life-threatening) compared to 16 in the propranolol group (51.19% vs 19.05%, P<0.05).
CONCLUSION:Propranolol may be the better choice in prophylaxis of variceal bleeding with similar effects and lower adverse events than with EVL.
