Plasma copeptin levels in elderly victims of massive cerebral infarction and its relationship to early death.
10.3969/j.issn.1672-7347.2012.06.008
- Author:
Ying LI
1
;
Dan YU
;
Yiqun XIE
Author Information
1. Department of Neurology, Affiliated Haikou Hospital of Central South University, Haikou 570208, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Aged, 80 and over;
Biomarkers;
blood;
Cerebral Infarction;
blood;
pathology;
Enzyme-Linked Immunosorbent Assay;
Female;
Glasgow Coma Scale;
Glycopeptides;
blood;
Humans;
Male;
Predictive Value of Tests;
Survival Analysis
- From:
Journal of Central South University(Medical Sciences)
2012;37(6):586-590
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate copeptin levels in elderly patients who have suffered massive cerebral infarction, and to establish its correlation with early death.
METHODS:Forty-nine elderly patients with acute massive cerebral infarction and an age-matched control group of thirty normal people were established. Plasma copeptin levels of patient group were measured by ELISA at 24 h, 36 h, 5 d, and 14 d after onset of infarction. Glasgow-Pittsburgh coma scale (GPCS) were recorded within 24 h after onset, and both results were graded. Based on the 14-day mortality, the patient was divided into a death group and a survival group, and the correlations between graded copeptin level and GPCS to mortality were analyzed, as well as the consistency and accuracy of prognosis.
RESULTS:Plasma copeptin levels in the patient group were no differences between the 24 h, 36 h and 5 d point, and that of the 14 d was lower than that of the other points. Copeptin levels were significantly higher than in the control group at each test point (P< 0.01 or P< 0.05). The copeptin level at 24 h among those dead by 14 days was higher than in those of the survival group (P<0.01). There were significant associations of early death (within 14 d) with copeptin levels and with GPCS grade(r=0.58, P<0.001, r=0.46, P<0.001, respectively). Copeptin level of the third-grade (>25.0 pmol/L) showed better consistency and coincidence rate than GPCS score (< 20) in predicting early death.
CONCLUSION:Plasma copeptin level was increased in early phases of acute massive cerebral infarction in elderly patients; it may have predictive value for early death.
