IEX-1: an unique protein in regulating apoptosis.
10.3969/j.issn.1672-7347.2011.03.015
- Author:
Ming ZHANG
1
;
Wu ZHU
;
Tao XIAO
Author Information
1. Institute of Osteocarcinoma, Second Xiangya Hospital, Central South University, Changsha 410011,China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
genetics;
Apoptosis Regulatory Proteins;
genetics;
physiology;
Cell Proliferation;
Humans;
Membrane Proteins;
genetics;
physiology;
Neoplasms;
genetics;
metabolism;
pathology;
Osteosarcoma;
metabolism;
pathology
- From:
Journal of Central South University(Medical Sciences)
2011;36(3):274-276
- CountryChina
- Language:Chinese
-
Abstract:
Immediate early response gene X-1 (IEX-1) gene was discovered by Charles in 1993, which plays an important role in regulating apoptosis. Previous studies demonstrated that IEX-1 gene was expressed in a variety of human tissues and played an important role in regulating apoptosis and cell growth through a positive or negative way. It can inhibit cell growth and apoptosis. However, it can also promote cell apoptosis. There is evidence that IEX-1 is involved in viral infections and cardiovascular diseases and it is highly expressed in many tumor tissues. The regulatory mechanisms for IEX-1 under normal and pathophysiological conditions are complicated and remain largely unknown. In this paper, we reviewed the recent progress of IEX-1 in different disease models.
