Evaluation of intraventricular dyssynchrony by quantitative tissue velocity imaging in rats of post-infarction heart failure.
10.3969/j.issn.1672-7347.2011.04.011
- Author:
Yan WANG
1
;
Wenhui ZHU
;
Xingxing DUAN
;
Yongfeng ZHAO
;
Wengang LIU
;
Ruizhen LI
Author Information
1. Department of Ultrasound, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Echocardiography, Doppler, Color;
Heart Failure;
diagnostic imaging;
etiology;
physiopathology;
Male;
Myocardial Infarction;
complications;
diagnostic imaging;
physiopathology;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Systole;
Ventricular Dysfunction, Left;
diagnostic imaging;
physiopathology
- From:
Journal of Central South University(Medical Sciences)
2011;36(4):340-345
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate intraventricular systolic dyssynchrony in rats with post-infarction heart failure by quantitative tissue velocity imaging combining synchronous electrocardiograph.
METHODS:A total of 60 male SD rats were randomly assigned to 3 groups: a 4 week post-operative group and an 8 week post-operation group (each n=25, with anterior descending branch of the left coronary artery ligated), and a sham operation group (n=10, with thoracotomy and open pericardium, but no ligation of the artery). The time to peak systolic velocity of regional myocardial in the rats was measured and the index of the left intraventricular dyssynchrony was calculated.
RESULTS:All indexes of the heart function became lower as the heart failure worsened except the left ventricle index in the post-operative groups. All indexes of the dyssynchrony got longer in the post-operative groups (P<0.05), while the changes in the sham operation group were not significantly different (P>0.05).
CONCLUSION:Quantitative tissue velocity imaging combining synchronous electrocardiograph can analyse the intraventricular systolic dyssynchrony accurately.
