Estimation of haplotypes based on DNA pooling.
10.3969/j.issn.1672-7347.2011.05.015
- Author:
Liu HE
1
;
Xun TANG
;
Yonghua HU
Author Information
1. Department of Epidemiology & Biostatistics, Key Laboratory of Epidemiolog of Ministry of Education, Health Science Center, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- MeSH:
Algorithms;
DNA;
genetics;
Gene Frequency;
genetics;
Gene Pool;
Genetic Variation;
genetics;
Genotyping Techniques;
Haplotypes;
genetics;
Humans
- From:
Journal of Central South University(Medical Sciences)
2011;36(5):457-460
- CountryChina
- Language:Chinese
-
Abstract:
DNA pooling, a fast and economic study strategy, is widely used in areas of scientific research. In spite of various limits, researchers are making their efforts to improve DNA pooling toward a more perfect direction, including allele frequency detection and estimation of haplotypes. In haplotype estimation, more and more analyzing Methods originated from the expectation-maximization algorithm have appeared, with improved accuracy and practicality, such as HaploPool algorithm and PoooL algorithm.
