Inflammatory factors promote the development of colorectal cancer.
10.3969/j.issn.1672-7347.2011.07.011
- Author:
Qin GUO
1
;
Shourong SHEN
;
Xiayu LI
;
Ke TANG
;
Weiwei ZHOU
Author Information
1. Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Adenomatous Polyps;
blood;
Adult;
Aged;
Colorectal Neoplasms;
blood;
immunology;
Cytokines;
blood;
Female;
Humans;
Immunoglobulins;
blood;
Inflammation;
Interleukin-12;
blood;
Interleukin-6;
blood;
Male;
Middle Aged;
Transforming Growth Factor beta1;
blood
- From:
Journal of Central South University(Medical Sciences)
2011;36(7):646-649
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the change of inflammatory factors at different stages of colorectal cancer (CRC).
METHODS:Thirty normal subjects, 30 patients with colorectal adenomatous polyps and 120 CRC patients at different stages were enrolled. IgG, IgM, and IgA levels, the inflammatory cytokines IL-2, 4, 6, 10, and 12 and the expression of TGF-β 1 and VEGF in the serum were analyzed by ELISA or immunoturbidimetry.
RESULTS:The serum concentrations of IL-12, TGF-β 1, and IL-6 in the CRC patients were statistically different compared with the normal and adenomatous polyps, and increased as the disease progressed (P<0.05). IL-6 reached the highest level in C phase of CRC.The serum concentrations of IL-2, IL-4, and IL-10 were significantly different among the groups. VEGF serum levels in CRC Phase A and Phase B compared with other groups were statistically different, but other serum concentrations had no significant difference (P>0.05). The serum level of IgG, IgM, and IgA in the 3 groups showed no significant difference (P>0.05).
CONCLUSION:The serum level of inflammatory cytokines TGF-β 1, IL-6, and IL-12 increases gradually with the development of CRC, which may change the microcirculation of patients with CRC, and promote the development of CRC.
