Sperm acrosome reaction detection in intrauterine insemination.
10.3969/j.issn.1672-7347.2011.07.018
- Author:
Ke ZHANG
1
;
Liqing FAN
;
Fei GONG
;
Wenbing ZHU
Author Information
1. Institute of Human Reproduction and Stem Cell Engineering, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Acrosome Reaction;
drug effects;
physiology;
Adult;
Calcimycin;
pharmacology;
Female;
Humans;
Infertility;
therapy;
Insemination, Artificial, Homologous;
methods;
Male;
Pregnancy;
Pregnancy Rate;
Spermatozoa;
physiology
- From:
Journal of Central South University(Medical Sciences)
2011;36(7):687-691
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between sperm acrosome reaction (AR) and the clinical pregnancy rate of intrauterine insemination (IUI).
METHODS:We detected the sperm spontaneous AR rate and Ca2+ ionophore A23187-induced AR rate in 128 patients who accepted IUI treatment, collected their clinical data and analysed the relationship between sperm AR rate and clinical pregnancy rate of IUI.
RESULTS:There was no statistical difference between the spontaneous AR rates in the pregnant group and the non-pregnant group (7.7% vs. 7.0%, P>0.05), but there was statistical difference between the induced AR rates(51.9 % vs. 43.5%, P<0.05). There was statistical difference in the clinical pregnancy rate among the 3 IUI groups divided by induced AR rate (≤20.0%, 20.1%-49.9%, and ≥50.0%; 4.8% vs. 12.5% vs. 18.6%, P<0.05).
CONCLUSION:The spontaneous AR rate has nothing to do with the clinical pregnancy rate of IUI, but the induced AR rate is associated with the clinical pregnancy rate of IUI.
