Genetics of autism spectrum disorders.
10.3969/j.issn.1672-7347.2011.08.001
- Author:
Hui GUO
1
;
Zhengmao HU
;
Jingping ZHAO
;
Kun XIA
Author Information
1. Central South University, Changsha 410078,China.
- Publication Type:Journal Article
- MeSH:
Autistic Disorder;
genetics;
Child, Preschool;
Epigenomics;
Genetic Heterogeneity;
Humans;
Infant
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):703-711
- CountryChina
- Language:English
-
Abstract:
Autism is a group of etiology and clinical heterogeneous neurodevelopmental disorders with an onset before 3 years old. It has 3 core characteristics: deficits in verbal communication; impairment of social interaction; restricted interests and repetitive behaviors. The incidence is increasing over time worldwide. Twin and family studies have demonstrated that autism has a high heritability (>90%). Although certain progress of autism genetic study has been made in the last decades and several autism susceptibility genes and loci have been identified, there are still about 70%-80% of patients for whom an autism-related genetic change cannot be identified.
