Sex difference in performance in elevated plus maze and hippocampal GluR1 level.
10.3969/j.issn.1672-7347.2011.08.009
- Author:
Xiaojun XIANG
1
;
Wei HAO
;
Therese A KOSTEN
Author Information
1. Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Anxiety;
metabolism;
physiopathology;
Behavior, Animal;
Female;
Hippocampus;
metabolism;
physiology;
Male;
Maze Learning;
physiology;
Rats;
Rats, Sprague-Dawley;
Receptors, AMPA;
metabolism;
physiology;
Sex Characteristics
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):750-753
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore whether sex difference exists in the performance in each arm of elevated plus maze (EPM) and GluR1 level in the hippocampus of female and male Sprague-Dawley rats.
METHODS:Eleven male and 10 female SD rats were tested for 5 minutes in the EPM. These rats were decapitated 30 min after testing. The left and right hippocampus were dissected. Samples were stored at -80 degree for protein extracting. Western blot was used to detect the GluR1 levels in the hippocampus.
RESULTS:Female rats exhibited less anxiety-like behaviors than male rats in the EPM (P<0.05).Female rats had lower GluR1 levels in total and left hippocampus than those of male rats (P<0.05).
CONCLUSION:Sex difference exists between female and male rats in the EPM and hippocampal GluR1.
