Efficacy of sequential therapy with pantoprazole in gastro esophageal reflux disease.
10.3969/j.issn.1672-7347.2011.08.019
- Author:
Fen WANG
1
;
Yan YANG
;
Qin GUO
;
Yan JIA
;
Shourong SHEN
Author Information
1. Department of Gastroenterology, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles;
administration & dosage;
therapeutic use;
Double-Blind Method;
Drug Administration Schedule;
Female;
Gastroesophageal Reflux;
drug therapy;
Humans;
Male;
Middle Aged;
Pantoprazole;
Proton Pump Inhibitors;
administration & dosage;
therapeutic use
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):799-802
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy of sequential therapy with pantoprazole in patients with gastro esophageal reflux disease (GERD).
METHODS:A total of 80 patients with GERD were double-blindedly randomized into 2 groups: 40 patients received sequential therapy with pantoprazole 40 mg injection, twice daily for 2 weeks, and then pantoprazole 40 mg oral administration,twice daily for 2 weeks; the other 40 patients received pantoprazole 40 mg oral administration alone,twice daily for 4 weeks. Doctors and patients recorded the severity and frequency of heartburn before and during the treatment. The curative effects of the 2 groups were compared.
RESULTS:The total effective rate in the sequential therapy group was higher than that of the oral administration group(95.0% vs 77.5%, P<0.05).
CONCLUSION:Pantoprazole sequential therapy is effective for GERD.
