MicroRNA-29 and fibrosis diseases.
10.3969/j.issn.1672-7347.2011.09.017
- Author:
Yan GE
1
;
Guochun CHEN
;
Lin SUN
;
Fuyou LIU
Author Information
1. Department of Nephropathy, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Extracellular Matrix;
genetics;
metabolism;
Humans;
Liver Cirrhosis;
blood;
genetics;
MicroRNAs;
blood;
genetics;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2011;36(9):908-912
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs,miR) are small, noncoding RNAs with 21-23 nucleotides. MicroRNA-29 (miR-29), a newly discovered miRNAs, is closely related with fibrosis diseases. MiR-29 directly suppresses the expression of a variety of extracellular matrix components and regulates signaling pathways associated with fibrosis. The serum level of miR-29 in patients with liver disease is consistent with the degree of liver cirrhosis.
