Photodynamic therapy for polypoidal choroidal vasculopathy.
10.3969/j.issn.1672-7347.2011.09.015
- Author:
Jiang YOU
1
;
Xiaojian GUO
Author Information
1. Department of Ophthalmology, Central South University, Changsha, China. jiangyou@163.com
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Choroid;
blood supply;
pathology;
Choroid Diseases;
drug therapy;
Choroidal Neovascularization;
drug therapy;
Female;
Humans;
Male;
Middle Aged;
Peripheral Vascular Diseases;
diagnosis;
drug therapy;
Photochemotherapy;
Photosensitizing Agents;
adverse effects;
therapeutic use;
Porphyrins;
therapeutic use;
Verteporfin;
Visual Acuity
- From:
Journal of Central South University(Medical Sciences)
2011;36(9):899-902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the effect of photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV).
METHODS:Eleven patients (11 eyes) with PCV who were diagnosed by fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA) and optic coherence tomography (OCT) were given PDT. The changes of best corrected visual acuity (BCVA), fundus photography, FFA and ICGA before and after the PDT were compared. Follow-up time varied from 6 to 30 months.
RESULTS:One month after the PDT, the BCVA was stable in 3 eyes, increased in 1 line in 3 eyes, increased in 2 lines in 2 eyes, and decreased in 2 lines in 3 eyes. FFA and ICGA showed no leakage in 5 eyes, leakage reduced in 3 eyes, and slight leakage in 3 eyes. At the last follow-up, the BCVA was stable in 5 eyes, increased in 1 line in 2 eyes, increased in 2 lines in 2 eyes, and decreased in 2 lines in 2 eyes. FFA and ICGA showed no leakage in 6 eyes, leakage reduced in 3 eyes, and slight leakage in 2 eyes. No severe systemic or local adverse effect was found during or after the PDT, except that 1 eye had vitreous hemorrhage 2 months after the PDT.
CONCLUSION:PDT may stop or reduce leakage of the lesion, facilitate the absorption of hemorrhage, edema and exudates, and stabilize or increase the patients' visual acuity. It could be a choice for PCV.
