Advances in molecular genetics research of IgA nephropathy.
10.3969/j.issn.1672-7347.2011.11.016
- Author:
Xiejia LI
1
,
2
;
Li XIAO
;
Lin SUN
;
Fuyou LIU
Author Information
1. Department of Nephropathy, Second Xiangya Hospital
2. Renal Institute, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chromosomes, Human, Pair 2;
genetics;
Chromosomes, Human, Pair 6;
genetics;
Genetic Association Studies;
Genetic Linkage;
Genetic Predisposition to Disease;
genetics;
Glomerulonephritis;
complications;
Glomerulonephritis, IGA;
etiology;
genetics;
Humans
- From:
Journal of Central South University(Medical Sciences)
2011;36(11):1120-1124
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin A nephropathy (IgAN), which can develop into end-stage renal disease, is the most common primary glomerulonephritis. The pathogenesis of IgAN is not clear. Many studies have confirmed that genetic susceptibility is associated with IgAN, and it belongs to polygenic disease. Some studies have found that IgAN is associated with chromosome 6q22-23, 2q36 by linkage analysis, and several candidate genes have been confirmed to be associated with IgAN, such as angiotensin converting enzyme, Fc fragment of IgA receptor, human leukocyte antigen. In recent years, as the progression of molecular genetics and the Human Genome Project, more attention has been paid to the role of genetic factors in the pathogenesis of IgAN.
