Expression of EphA7 and MTDH and clinicopathological significance in the squamous cell cancer of the tongue.
10.3969/j.issn.1672-7347.2011.12.012
- Author:
Nianfeng DENG
1
;
Yunzhi FENG
Author Information
1. Department of Stomatology, Second Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cell Adhesion Molecules;
metabolism;
Female;
Humans;
Male;
Middle Aged;
Prognosis;
Receptor, EphA7;
metabolism;
Tongue Neoplasms;
metabolism;
pathology
- From:
Journal of Central South University(Medical Sciences)
2011;36(12):1195-1198
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the expression levels of EphA7 and MTDH and detect their clinicopathological significance in the peritumoral normal tissues and the squamous cell cancer of the tongue.
METHODS:Envision immunohistochemistry was used to assay the expression levels of EphA7 and MTDH in the conventional paraffin-embedded sections from specimens of squamous cell cancer (n=45) and peritumoral normal tissues (n=10).
RESULTS:The positIVe rates of EphA7 and MTDH were significantly higher in the squamous cell cancer than those in the peritumoral normal tissues ( χ(2)(EphA7)=4.14; χ(2)(MTDH)= 5.25; P < 0.05). The positIVe rates of EphA7 and MTDH expression were significantly lower in the cases of histological grade I-II,clinical stage I-II, and no-metastasis of neck lymph node than those in the histological grade III-IV, clinical stage III-IV, and metastasis of neck lymph node (P <0.05 or P <0.01).
CONCLUSION:The expression levels of EphA7 and/or MTDH might have important effect on the carcinogenesis and progression of tongue cancer. Overexpression of EphA7 and/or MTDH might have poor prognosis.
