Expression of galectin-3 and Sambucus nigra agglutinin and its clinicopathological significance in benign and malignant lesions of breast.
10.3969/j.issn.1672-7347.2010.06.008
- Author:
Gannong CHEN
1
;
Qiongyan ZOU
;
Zhulin YANG
Author Information
1. Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011,China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Breast Neoplasms;
metabolism;
pathology;
Female;
Fibrocystic Breast Disease;
metabolism;
pathology;
Galectin 3;
genetics;
metabolism;
Humans;
Middle Aged;
Mucin-1;
metabolism;
Plant Lectins;
genetics;
metabolism;
Prognosis;
Receptors, Estrogen;
metabolism;
Ribosome Inactivating Proteins;
genetics;
metabolism;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(6):584-589
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of galectin-3 (gal-3) and Sambucus nigra agglutinin (SNA) and determine their clinicopathological significance in breast cancers and benign breast lesions.
METHODS:Envison immunohistochemistry for staining gal-3 expression, and ABC affinity-cytochemistry to detect SNA expression were used in paraffin-embedded slides from specimens of breast cancers (n=60) and benign lesions (n=30).
RESULTS:The positive rates and scoring means of gal-3 and SNA were significantly higher in breast cancer (48.3%, 2.07 +/- 2.25, 2.12 +/- 2.26) than those in benign lesions (26.7%, 1.03 +/- 1.63, 1.07 +/- 1.59, P < 0.05). The scoring means of gal-3 and SNA expression were significantly lower in the positive cases of estrogen receptor (ER) and the negative ones of CA15-3 than those in the negative cases and the positive ones (P < 0.05).The survival analysis of Kaplan-Meier showed the 5-year survival rate and mean survival period were significantly lower in the gal-3 or SNA expression positive cases than those in the negative cases of breast cancer (P<0.01).
CONCLUSION:The expressive level of gal-3 and SNA lectins might have important effect on the carcinogenesis, progression and biologic behaviors of breast cancer. The positive cases of gal-3 and /or SNA expression might have poor prognosis.
