Expression of Calponin-1 and Transgelin in human uterine smooth muscles in non-labor and labor situation.
10.3969/j.issn.1672-7347.2010.10.007
- Author:
Qian CHEN
1
;
Yonghong GU
;
Changju ZHOU
;
Lingyu HU
;
Changying PENG
Author Information
1. Department of Pathology, Third Xiangya Hospital, Central South University, Changsha 410013, China. cqj12@yeah.net
- Publication Type:Journal Article
- MeSH:
Adult;
Calcium-Binding Proteins;
genetics;
metabolism;
Female;
Humans;
Labor Onset;
metabolism;
Microfilament Proteins;
genetics;
metabolism;
Muscle Proteins;
genetics;
metabolism;
Myometrium;
metabolism;
Pregnancy;
Uterine Contraction;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2010;35(10):1073-1079
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of Calponin-1 and Transgenlin in the uterine smooth muscles during normal labor on-sets, and to evaluate their effect on initiating the normal labor.
METHODS:A total of 14 uterine bodies and lower segments of human pregnancy were divided to a non-labor group (NIL) and a labor group(IL). Immunohistochemical technology and Western blot were used to determine the expression of Calponin-1 and Transgelin in the 2 groups.
RESULTS:Immunohistochemical detection and Western blot showed that Calponin-1 protein in the uterine smooth muscle tissue of the body and the lower uterine segment of smooth muscle tissues had significant difference (P<0.05). The expression of Transgelin in the uterine body smooth muscle tissue in the IL was higher than that in the NIL(P<0.05). In the lower uterine segments of the smooth muscle, the expression of Transgelin was not significantly different in the 2 groups (P>0.05).
CONCLUSION:Calponin-1 of the uterine smooth muscle and Transgelin of the uterine body smooth muscle may involve in the regulation of uterine smooth muscle contractility, which is closely related to child birth launch.
