Cytomegalovirus infection and immunosuppressant treatment in allogeneic hematopoietic stem cell transplantation recipients.
10.3969/j.issn.1672-7347.2010.11.008
- Author:
Weimin XIE
1
;
Xi ZHANG
;
Guihua PENG
;
Bin YI
;
Wen'en LIU
;
Baiyun ZHONG
;
Zijuan JIAN
;
Yunrong FAN
Author Information
1. Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Cyclosporine;
adverse effects;
blood;
therapeutic use;
Cytomegalovirus;
isolation & purification;
Cytomegalovirus Infections;
prevention & control;
DNA, Viral;
blood;
Female;
Ganciclovir;
therapeutic use;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Immunosuppressive Agents;
adverse effects;
blood;
therapeutic use;
Leukemia;
therapy;
Male;
Retrospective Studies;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(11):1162-1166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation between peripheral blood cytomegalovirus (CMV) DNA level and cyclosporine A (CsA) plasma concentration among allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients who received immunosuppressant treatment, and to evaluate the potential clinical value.
METHODS:A total of 32 allo-HSCT patients were enrolled and their data were analyzed retrospectively. Ganciclovir was used to prevent CMV infection before the transplantation. Routine fluorescence PCR was admitted to test the blood CMV DNA level. The patients were divided into 2 groups: a CMV DNA positive group and a CMV DNA negative group. Enzyme multiplied immunoassay technique was adopted regularly to monitor the blood CsA concentration. The correlation between CMV DNA level and CsA concentration was analyzed.
RESULTS:The CMV infection rate in patients who received allo-HSCT was 53.13%. The blood CsA concentration in the CMV DNA positive group was significantly higher than that in the CMV DNA negative group (P<0.05). Through the ROC curve, the area under the curve on Day 1, 7, and 14 had statistical significance compared with 0.5, and the corresponding blood CsA concentration was 203.15, 215.55, and 302.65 ng/mL, respectively.
CONCLUSION:Immunosuppressive drug concentration can affect the dynamic changes of CMV DNA. High blood CsA concentration may be one of the reasons for CMV infection. Monitoring the blood CsA concentration may provide guidance for clinical treatment.
