Association between polymorphism of rs3212855 and rs5515 of KLK1 gene with cerebral hemorrhage in Changsha Han population.
10.3969/j.issn.1672-7347.2010.12.004
- Author:
Le ZHANG
1
;
Zhongyang HU
;
Jie YANG
;
Shuyu LI
;
Yi ZENG
;
Baoqiong LIU
;
Xiaoping DU
;
Jian XIA
;
Yunhai LIU
;
Hongwei XU
;
Qidong YANG
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Cerebral Hemorrhage;
genetics;
China;
ethnology;
Female;
Genotype;
Humans;
Kallikreins;
genetics;
Male;
Middle Aged;
Polymorphism, Single Nucleotide;
genetics;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1225-1229
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association between single nucleotide polymorphism (SNPs) of KLK1 gene and cerebral hemorrhage in Changsha Han population.
METHODS:We enrolled 273 patients with cerebral hemorrhage and 140 normal people. The SNPs (including rs3212855 and rs5515) of KLK1 gene were analyzed by Snapshot method and direct sequencing.
RESULTS:We found rs5515 was not a polymorphic site in Changsha Han population. Genotype and allele frequency in rs3212855 were not different between patients with cerebral hemorrhage and the controls (P>0.05). The blood pressure level was not different between the genotype subgroups.
CONCLUSION:Neither rs5515 nor rs3212855 is associated with cerebral hemorrhage.
