Correlation between multi-slice spiral CT pulmonary perfusion imaging and cavity of microvessel in lung cancer.
10.3969/j.issn.1672-7347.2010.12.007
- Author:
Jinkang LIU
1
;
Zeng XIONG
;
Chengping HU
;
Moling ZHOU
;
Hui ZHOU
;
Wei CHEN
;
Yu XIA
Author Information
1. Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Capillaries;
pathology;
Carcinoma, Non-Small-Cell Lung;
blood supply;
diagnostic imaging;
pathology;
Diagnosis, Differential;
Female;
Humans;
Lung Neoplasms;
blood supply;
diagnostic imaging;
pathology;
Male;
Neovascularization, Pathologic;
diagnostic imaging;
Solitary Pulmonary Nodule;
blood supply;
diagnostic imaging;
pathology;
Tomography, Spiral Computed;
methods
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1242-1247
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relation between multi-slice spiral CT pulmonary perfusion imaging and the cavity of microvessel in lung cancer.
METHODS:Altogether 36 patients with malignant nodules who underwent multi-slice spiral CT perfusion scan were examined.The perfusion parameters were collected and compared with the microvessel density (MVD), the incomplete lumen MVD, and the differentiation of non-small cell lung cancer (NSCLC). The patients were divided into a hyper-perfusion group and a hypo-perfusion group by the value of perfusion parameters. The maturity of microvessel and the degree of differentiation in NSCLC between the 2 groups was analyzed.
RESULTS:Blood flow (BF), blood volume (BV), and peak enhancement image(PEI) of the malignant nodules were (39.7±11.5) mL/(100 mg.min), (8.6±3.8)mL/100 g, and (20.1±8.6)HU, respectively. There was a positive correlation between PEI and MVD(r=0.645,P<0.01), and a negative correlation between BF and MVD(r=-0.280,P=0.048). There were negative correlations of BF, BV, PEI with the incomplete lumen MVD (P<0.05). BF had the highest correlation coefficient(r=-0.882,P<0.01).The incomplete lumen MVD of the hyper-perfusion group was significantly lower than that of hypo-perfusion group (P<0.05),but there was no significant difference in MVD between the 2 groups. There were negative correlations of BF, BV,PEI with the degree of differentiation (P<0.05). BF had the highest correlation coefficient(r=-0.751,P<0.01).
CONCLUSION:Multi-slice spiral CT pulmonary perfusion imaging is helpful to evaluate the degree of differentiation and status of angiogenesis in lung cancer, and its basis is the cavity of microvessel.
