Association of serum follicle stimulating hormone with osteoprotegerin, leptin, TGF-β1, and TGF-β2 in women.
10.3969/j.issn.1672-7347.2010.12.011
- Author:
Xiaohong WANG
1
;
Ruijuan ZHANG
;
Hui XIE
;
Xianping WU
Author Information
1. Institute of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cross-Sectional Studies;
Female;
Follicle Stimulating Hormone;
blood;
Humans;
Leptin;
blood;
Middle Aged;
Osteoprotegerin;
blood;
Transforming Growth Factor beta1;
blood;
Transforming Growth Factor beta2;
blood;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1266-1271
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the relation between follicle-stimulating hormone (FSH) level and bone metabolism-related cytokines in women.
METHODS:A cross-sectional study of 703 healthy Chinese women, aged 20-80 years, was conducted. Serum FSH, osteoprotegerin (OPG), leptin, transforming growth factor-beta 1 (TGF-β1), and transforming growth factor-beta 2 (TGF-β2) were detected.
RESULTS:Serum FSH was positively correlated with OPG (r=0.447, P<0.01) and TGF-β2 (r=0.344, P<0.01), and negatively correlated with TGF-β1 (r=-0.374, P<0.01). After adjustment of age, a negative correlation was found between FSH and leptin (r=-0.265, P<0.01). The multiple linear stepwise regression analysis showed that serum FSH was a negative determinant factor of TGF-β1, and 22.6% changes in TGF-β1 was determined by FSH. FSH was, however, a positive determinant factor of OPG and TGF-β2, and 9.9% and 1.1% of the effect on OPG and TGF-β2 was performed by FSH, respectively. Serum FSH almost had no effect on leptin.
CONCLUSION:Serum FSH level in adult women is related to bone metabolism-related cytokines, such as TGF-β1, OPG, and TGF-β2.
