Effect of ulinastatin on thromboxane B₂ and deep vein thrombosis in elderly patients after hip joint replacement.
10.3969/j.issn.1672-7347.2010.12.013
- Author:
Yeying GE
1
;
Jianqing CHENG
;
Wenjiao XI
;
Shufen ZHENG
;
Yamei KANG
;
Yandi JIANG
Author Information
1. Department of Anesthesiology, Ningbo 6th Hospital, Ningbo Zhejiang 315040, China. geyeying59198@163.com
- Publication Type:Journal Article
- MeSH:
Aged;
Aged, 80 and over;
Arthroplasty, Replacement, Hip;
adverse effects;
Female;
Glycoproteins;
therapeutic use;
Hip Fractures;
surgery;
Humans;
Male;
Thromboxane B2;
blood;
Trypsin Inhibitors;
therapeutic use;
Ultrasonography;
Venous Thrombosis;
diagnostic imaging;
etiology;
prevention & control
- From:
Journal of Central South University(Medical Sciences)
2010;35(12):1278-1281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the effect of ulinastatin on plasma thromboxane B(2) and deep vein thrombosis(DVT) in elderly patients after hip joint replacement.
METHODS:Eighty ASAI-IIpatients aged 65-81 years undergoing hip joint replacement were randomly divided into 4 groups (n=20): Group U1 (ulinastatin 5 000 U/kg);Group U2 (ulinastatin 10 000 U/kg); Group U3 (ulinastatin 20 000 U/kg); and Group C (the same volume of saline as control).The blood samples were collected at 5 time points: preoperation (T(1)), immediately after the operation (T(2)), 1 d (T(3)), 2 d (T(4)) and 3 d after the operation (T(5)), respectively. Thromboxane B(2) was detected, and DVT was also examined through color Doppler ultrasonography 3 d after the operation.
RESULTS:Compared with T(1), the level of thromboxane B(2) significantly increased in Group C at T(2)-5, in Group U1 at T(2-4), in Group U2 and U3 at T(2) (P<0.01). Compared with Group C, the concentration of thromboxane B(2) decreased in Group U1 at T(2-3), in Group U2 and U3 at T(2-4) (P<0.01). Compared with Group U1, thromboxane B(2) significantly decreased in Group U2 and U3 at T(2-4) (P<0.01).The incidence rate of DVT was 40% in Group C, 10% in Group U1. There was no incidence of DVT in the Group U2 and U3 (P>0.05).
CONCLUSION:Ulinastatin can inhibit blood thromboxane B(2) level in dose dependent manner and prevent DVT in elderly patients after hip joint replacement.
