Change of serum MCP-1 level and CCR2 protein expression in isolated monocytes in patients with acute coronary syndrome.
- Author:
Yangui WANG
1
;
Zhaoqian LIU
;
Tianlun YANG
Author Information
1. Department of Gerontology, Hunan Provincial Peopleos Hospital, Changsha 410001, China. zhangmingkui001@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Acute Coronary Syndrome;
blood;
Adult;
Case-Control Studies;
Chemokine CCL2;
blood;
Female;
Humans;
Male;
Middle Aged;
Monocytes;
metabolism;
Receptors, CCR2;
blood
- From:
Journal of Central South University(Medical Sciences)
2009;34(4):318-322
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the change of serum MCP-1 level and CCR2 expression in isolated monocytes in patients with acute coronary syndrome (ACS) and its possible relationship with ACS pathogenesis.
METHODS:Thirty ACS patients and 30 healthy controls were enrolled. Serum MCP-1 levels were determined by ELISA in all subjects. The protein expression of CCR2 in isolated monocytes was assessed by flow cytometry.
RESULTS:Serum MCP-1 concentrations in ACS patients were higher than those in healthy controls (P<0.05) and the ratio of CCR2 protein expression in monocytes in ACS patients was higher than that in healthy controls (P<0.01).
CONCLUSION:The serum MCP-1 concentrations and protein expression of CCR2 in ACS patients are significantly higher than those in healthy controls, which might be associated with the pathogenesis of ACS.
