Clinicopathologic features and diagnosis of 18 patients with angioimmunoblastic T-cell lymphoma.
- Author:
Xiaoyu YUAN
1
;
Fangping CHEN
;
Dandong BI
;
Xielan ZHAO
;
Qiongqiong HE
;
Qun LI
Author Information
1. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Chemokine CXCL13;
metabolism;
Female;
Humans;
Immunoblastic Lymphadenopathy;
diagnosis;
metabolism;
pathology;
Lymphoma, T-Cell, Peripheral;
diagnosis;
metabolism;
pathology;
Male;
Middle Aged;
Retrospective Studies;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2009;34(6):523-526
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical and pathologic features of angioimmunoblastic T-cell lymphoma(AITL) and provide evidence for diagnosis.
METHODS:Eighteen AITL patients (9 males and 9 females aged from 14 to 70 years) were retrospectively analyzed in Xiangya Hospital of Central South University from July 2002 to September 2007.
RESULTS:Characteristic features at the presentation of AITL included generalized lymphadenopathy, fever, splenomegaly, and skin rashes with polyclonal hyper-gammaglobulinemia and other hematological abnormalities (such as Coombs-positive hemolytic anemia), which often involved the bone marrow and had well-described histologic features. The positive rate for CXCL13 was 93.3%.
CONCLUSION:Repeated lymphadenbiopsy is helpful for AITL diagnosis. Routine histological and immunohistochemical examinations (especially including CXCL13) play significant role in the diagnosis and differential diagnosis of AITL.
