Effect of neoadjuvant chemotherapy on cervical carcinoma.
- Author:
Lanqin CAO
1
;
Xin LI
;
Xinguo LI
;
Yi ZHANG
Author Information
1. Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University, Changsha 410008, China. caolanqin@163.com
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
drug therapy;
mortality;
surgery;
Adult;
Carcinoma, Squamous Cell;
drug therapy;
mortality;
surgery;
Female;
Humans;
Middle Aged;
Neoadjuvant Therapy;
methods;
Prognosis;
Survival Rate;
Uterine Cervical Neoplasms;
drug therapy;
mortality;
surgery
- From:
Journal of Central South University(Medical Sciences)
2009;34(6):527-530
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of neoadjuvant chemotherapy on cervical carcinoma and its association with clinical data.
METHODS:A total of 97 patients with stage Ib2 approximately IIIa of cervical cancinoma were treated with neoadjuvant chemotherapy. The effect of chemotherapy, factors associated with outcome of chemotherapy, and histology were analyzed.
RESULTS:Effective rate of chemotherapy was 86.6% which was associated with clinical stage and histology. Eight-four patients received radical hysterectomy. The histological grade of 17 patients was lowered, lymph nodes in 19 patients were positive, and 6 patients had parametrium invasion. One patient died within 1 year after the operation, and 5 patients recurred.
CONCLUSION:The effect of neoadjuvant chemotherapy for locally advanced cervical cancinoma is good. Surgery after chemotherapy can improve the prognosis and 5-year survival rate.
