Effect of Tongxinluo on endothelial function and hypersensitive C-reactive protein in acute coronary syndrome patients undergoing percutaneous coronary intervention.
- Author:
Qilin MA
1
;
Saidan ZHANG
;
Yanggen NING
;
Xiaoqun PU
;
Guolong YU
;
Zhaofen ZHENG
;
Xiaobin CHEN
;
Ke HU
;
Tianlun YANG
Author Information
1. Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Acute Coronary Syndrome;
blood;
physiopathology;
therapy;
Aged;
Angioplasty, Balloon, Coronary;
methods;
C-Reactive Protein;
metabolism;
Drugs, Chinese Herbal;
therapeutic use;
Endothelium, Vascular;
drug effects;
physiopathology;
Female;
Humans;
Male;
Middle Aged;
Phytotherapy
- From:
Journal of Central South University(Medical Sciences)
2009;34(6):550-554
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the effect of Tongxinluo on the endothelial function and hypersensitive C-reactive protein (hs-CRP) in acute coronary syndrome patients undergoing percutaneous coronary intervention(PCI).
METHODS:Thirty-three patients with unstable angina pectoris and 6 patients with acute myocardial infarction who underwent PCI for stenotic lesions of the coronary artery were enrolled. The patients were randomly assigned to a conventional group (n = 19) which took routine treatment or a tongxinluo group (n = 20) which took Tongxinluo(4 capsules once, 3 times per day) at the base of routine treatment after PCI. Nitric oxide synthase (NOS), nitric oxide (NO), endothelium-dependent vasodilation which was evaluated in the brachial artery flow mediated diameter(FMD) and hs-CRP were measured before the PCI and 24 hours and 3 months after the PCI. The correlation between NO and hs-CRP was analyzed.
RESULTS:NOS, NO, and FMD in the 2 groups 24 hours after the PCI were significantly lower than those before the PCI(P < 0.05), but hs- CRP obviously increased (P < 0.05). NOS, NO, and FMD 3 months after the PCI in the 2 groups were significantly higher than those before the PCI (P < 0.05 or P < 0.01), but hs-CRP obviously decreased (P < 0.01).All indexes mentioned above in the Tongxinluo group showed greater changes than those of the conventional group(P < 0.05). NO was negatively correlated with hs-CRP (r = -0.3219, P<0.01).
CONCLUSION:Tongxinluo capsules have obvious beneficial effect on endothelial function and anti-inflammation in acute coronary syndrome patients undergoing PCI, by directly acting on the endothelium and indirectly inhibiting inflammation.
