Clinicopathologic characteristics, diagnosis, and treatment of 30 patients with hereditary nonpolyposis colorectal cancer.
- Author:
Heli LIU
1
;
Zhongshu YAN
;
Guoqing LIAO
;
Hongling YIN
;
Xiaoyong XIE
Author Information
1. Department of General Surgery,Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adaptor Proteins, Signal Transducing;
genetics;
metabolism;
Adenocarcinoma;
diagnosis;
genetics;
pathology;
surgery;
Aged;
Case-Control Studies;
Colorectal Neoplasms, Hereditary Nonpolyposis;
diagnosis;
genetics;
pathology;
surgery;
Endometrial Neoplasms;
pathology;
Female;
Humans;
Male;
Middle Aged;
MutL Protein Homolog 1;
MutS Homolog 2 Protein;
genetics;
metabolism;
Mutation;
Neoplasms, Second Primary;
pathology;
Nuclear Proteins;
genetics;
metabolism;
Retrospective Studies
- From:
Journal of Central South University(Medical Sciences)
2009;34(8):757-761
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinicopathologic and molecular characteristics of hereditary nonpolyposis colorectal cancer (HNPCC), and to improve the level of diagnosis and treatments of HNPCC.
METHODS:Thirty HNPCC patients (HNPCC group) who were treated in Xiangya Hospital were retrospectively analyzed, and 25 patients with sporadic colorectal cancer in the same duration were randomly chosen as a control group. The onset of age, location of tumor, pathological type, treatment method, and prognosis were compared in the 2 groups. The expression loss rate of mismatch repair gene (MMR) MLH1 and MSH2 in the 2 groups was detected by immunohistochemistry.
RESULTS:The onset age in the HNPCC group was earlier than that in the control group (P<0.05). The rate of proximal colonic tumor the occurrence of multiple tumors, and the proportion of well differentiated adenocarcinoma in the HNPCC group were all higher than those in the control group (P<0.05). The expression loss rate of MLH1 and MSH2 in the HNPCC group was higher than that in the control group (P<0.05). One third in the HNPCC group received subtotal proctocolectomy. The prognosis of HNPCC patients was comparable with that of patients with sporadic colorectal cancer (P>0.05).
CONCLUSION:HNPCC patients are characterized with early onset associating with multiple tumors. The accuracy of diagnosis can be improved by combining the detection of MMR gene. Optimal surgical treatment and close follow-up may bring good result to HNPCC patients.
