Analysis of adverse drug reaction of gatifloxacin in Hunan province from Aug. 2003 to Jul. 2007.
- Author:
Sheng DENG
1
;
Yanchun HE
;
Tao YIN
;
Liping LONG
;
Wei ZHANG
Author Information
1. Department of Pharmacy, Central South University, Changsha 410008,China. yjsd2003@163.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Adverse Drug Reaction Reporting Systems;
Aged;
Aged, 80 and over;
Anti-Infective Agents;
adverse effects;
Child;
Child, Preschool;
China;
Drug-Related Side Effects and Adverse Reactions;
Female;
Fluoroquinolones;
adverse effects;
Gatifloxacin;
Humans;
Male;
Middle Aged;
Retrospective Studies;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2009;34(1):49-53
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To summarize the occurrences of adverse drug reactions (ADR) of gatifloxacin, and to guide the rational usage of antibacterial agents in clinical practice in the future.
METHODS:A total of 1 077 ADR patient who received gatifloxacin were retrospectively studied in Hunan province from August 2003 to July 2007.
RESULTS:Gatifloxacin could cause multi-system and multi-organ ADRs with wide variety of clinical manifestations. Of the 1 077 ADR patients, ADR incidence rate was slightly lower in males than that in females, the age of 821 (76.23%) ADR patients were 20 approximately 59 years; 905 (84.03%) were administered intravenously; and 682 (33.07%) had severe lesions of the digestive system, followed by lesions of the skin and the appendants (490 cases, 23.76%) and the nervous system (298 cases, 14.45%).
CONCLUSION:ADR caused by gatifloxacin should be monitored and reported so as to reduce or avoid ADR.
