Effect of yizhi jiannao granules on the expression of Pin1 and HMGB1 mRNA in the hippocampus of SAMP8 mice.
- Author:
Huiling WANG
1
;
Keli DONG
;
Guangcheng LI
;
Xianwen PENG
;
Hong ZHU
Author Information
1. Changsha Mental Hospital, Changsha 410004,China.
- Publication Type:Journal Article
- MeSH:
Aging;
drug effects;
metabolism;
Alzheimer Disease;
metabolism;
Animals;
Drugs, Chinese Herbal;
pharmacology;
HMGB1 Protein;
genetics;
metabolism;
Hippocampus;
metabolism;
Male;
Mice;
NIMA-Interacting Peptidylprolyl Isomerase;
Peptidylprolyl Isomerase;
genetics;
metabolism;
RNA, Messenger;
genetics;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2009;34(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of yizhi jiannao granule concentration fluid (YCF) on the expression of peptidyl-prolyl-cis-trans isomerase A (Pin1) and high mobility group box 1 (HMGB1) mRNA in the hippocampus of senescence accelerated mice Senile-Prone8(SAMP8).
METHODS:Six-month old SAMP8 mice were randomly divided into a YCF group and a model group. Six-month old SAMP8 mice were served as a normal control group. The YCF group was ravaged, while the model group and the normal control group were gavaged with double-distilled water for 8 weeks. The hippocampus was taken out for examination. The expression of Pin1 and HMGB1 mRNA was measured by RT-PCR.
RESULTS:In the YCF group, the level of Pin1 mRNA increased, and the level of HMGB1 mRNA decreased compared with that of the model group.
CONCLUSION:Yizhi jiannao granules can prevent Alzheimer's disease by increasing the Pin1 level and decreasing the HMGB1 level.
