Association of cathepsin L with coronary heart disease and its risk factors.
- Author:
Jun WANG
1
;
Yingxian LIU
;
Xiangping LI
;
Daoquan PENG
;
Zhen TAN
;
Hongmin LIU
;
Yingnan QIN
;
Yanqiong XUE
Author Information
1. Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Cathepsin L;
blood;
Coronary Disease;
blood;
pathology;
Female;
Humans;
Logistic Models;
Male;
Middle Aged;
Risk Factors
- From:
Journal of Central South University(Medical Sciences)
2009;34(2):130-134
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship of cathepsin L (CatL) with coronary heart disease (CHD), severity of coronary stenosis and risk factors of CHD.
METHODS:A total of 137 CHD patients and 48 controls were included in the study, to determined the serum levels of CatL, high sensitive C reactive protein (hs-CRP), fasting glucose (FBS), total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1(Apo-A1) and apolipoprotein B. All the subjects were invited for a coronary angiography, using the sum of the Gensini scores to assess the severity of coronary artery stenosis.
RESULTS:Serum CatL levels were significantly higher in CHD patients (5.63 +/= 0.12 microg/L) than non-CHD subjects (3.93 +/= 0.22 microg/L, P<0.01). CatL was an independent risk factor of CHD in Logistic regression analysis [Exp(B)=2.341, 95%CI 1.567 approximately 3.496, P<0.01]. Serum CatL levels were associated positively with the Gensini scores(r=0.228, P<0.01); In fact, CatL was an independent correlator of Gensini scores (P<0.05). CatL inversely associated with HDL-C (r=-0.228, P<0.01) and ApoA1(r=-0.187, P<0.05), and positively with FBS(r=0.161, P<0.05).
CONCLUSION:CatL is involved in the pathogenesis of CHD. Serum CatL levels could reflect the severity of coronary luminal narrowings. CatL might participate in glucose and lipid metabolic disorders.
