Expression of ubiquitin and cullin-1 and its clinicopathological significance in benign and malignant lesions of the lung.
- Author:
Zaimei PENG
1
;
Huifang WANG
;
Changting SHAN
Author Information
1. Department of Emergency, Second Xiangya Hospital, Central South University, Changsha 410011, China. zaimeipg@hotmail.com
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
metabolism;
pathology;
Adult;
Aged;
Carcinoma, Squamous Cell;
metabolism;
pathology;
Cullin Proteins;
genetics;
metabolism;
Female;
Humans;
Immunohistochemistry;
Lung Neoplasms;
metabolism;
pathology;
Lymphatic Metastasis;
Male;
Middle Aged;
Prognosis;
Ubiquitin;
genetics;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2009;34(3):204-209
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the expression of ubiquitin and cullin-1 (cul-1) in benign and malignant lesions of the lung and to determine their clinicopathological significance.
METHODS:EnVison immunohistochemistry was used to detect the expression of ubiquitin and cul-1 in the conventional paraffin-embedded sections from the specimens of lung cancer (n = 80) and benign lesion tissues of the lung (n = 20). We also analyzed the relation of the expression of ubiquitin and cul-1 with the clinical stage, differentiation, and with or without lymphatic metastasis.
RESULTS:The positive rates of ubiquitin and cul-1 were significantly higher in lung cancer (51.3% and 60.0%) than those in benign lesion tissues of the lung (20.0% and 30.0%; P < 0.05). Positive rates of ubiquitin and cul-1 were all significantly lower in the middle and high-differentiated, Stage I approximately II, and no lymphatic metastasis patients with lung cancer than those in no- or low-differentiated, Stage III approximately IV, and lymphatic metastasis patients with lung cancer tissues (P < 0.01 approximately 0.05). High consistency was found between the positive expression of ubiquitin and cul-1 in lung cancer tissues (chi(2) = 4.04, P < 0.05).
CONCLUSION:Expression of ubiquitin and cul-1 in lung cancer tissues may be closely related to the carcinogenesis, progression, clinical biological behaviors, and prognosis of lung cancer.
