Transplantation of kidneys from HBV-positive or HCV-positive donors.
- Author:
Xubiao XIE
1
;
Gongbin LAN
;
Longkai PENG
;
Fenghua PENG
;
Yu WANG
;
Chunhua FANG
;
Manhua NIE
Author Information
1. Department of Urological Organ Transplantation, Center of Organ Transplantation, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Female;
Follow-Up Studies;
Graft Survival;
Hepatitis B;
prevention & control;
transmission;
Hepatitis B Antibodies;
blood;
Hepatitis C;
prevention & control;
transmission;
Hepatitis C Antibodies;
blood;
Humans;
Kidney Transplantation;
adverse effects;
immunology;
Male;
Middle Aged;
Tissue Donors;
Young Adult
- From:
Journal of Central South University(Medical Sciences)
2009;34(3):259-263
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effect and safety of transplantation of kidneys from HBV-positive or HCV-positive donors.
METHODS:From January 2002 to June 2006, 283 kidney transplantations were performed in Second Xiangya Hospital. Altogether 57 recipients were HBV-positive, including 31 from donors with viral B hepatitis (DB + /RB +), and 26 from donors with HBV-negative (DB - /RB +). Nineteen patients with hepatitis C virus underwent a kidney transplantation, including 6 who received kidneys from anti-HCV-positive donors (DC + /RC +) and 13 from seronegative donors (DC - /RC +). Recipient's liver function, acute rejection, graft survival, and patient survival had been observed for an average follow-up of 14 months.
RESULTS:No significant difference was observed between the DB + /RB + group and DB - /RB + group, or the DC + /RC + group and DC - /RC + group in the rate of liver disfunction, acute rejection, graft survival, and patient survival.
CONCLUSION:Kidney transplantations from HBV-positive or HCV-positive donors into the matched serology-positive recipients is safe in the short term, and the long-term results need further observation.
