Effect of antipsychotic drugs on life quality of schizophrenic patients: one year follow-up study.
- Author:
Maosheng FANG
1
;
Lehua LI
;
Jingping ZHAO
;
Honghui CHEN
;
Meng YE
;
Xiaofeng GUO
;
Zheng LU
;
Xueli SUN
;
Chuanyue WANG
;
Shiping XIE
;
Bin HU
;
Tiansheng GUO
;
Cui MA
;
Bo WANG
;
Luxian LÜ
;
Na LIU
;
Hong DENG
;
Qi CHEN
;
Xiaofang SHANG
;
Fajin GONG
;
Xiyan ZHANG
;
Xiaolin HE
;
Jianchu ZHOU
;
Yingli ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Antipsychotic Agents; therapeutic use; Benzodiazepines; therapeutic use; Dibenzothiazepines; therapeutic use; Female; Follow-Up Studies; Humans; Male; Middle Aged; Olanzapine; Quality of Life; Quetiapine Fumarate; Schizophrenia; drug therapy; Surveys and Questionnaires; Young Adult
- From: Journal of Central South University(Medical Sciences) 2009;34(9):850-855
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the effect of 7 antipsychotic drugs on the life quality of schizophrenia patients including chlorpromazine, sulpiride, clozapine, risperidone, olanzapine, quetiapine, and aripiprazole.
METHODS:A total of 1,227 stable schizophrenic patients within 5 years onset who took 1 of the 7 study medications as maintenance treatment were followed up for 1 year at 10 China sites. Patients were evaluated by the short form-36 health survey (SF-36) at the baseline and at the end of 1 year.
RESULTS:The life quality was improved obviously at the end of the follow-up. There was significant difference in body pain, vitality, and mental health (P<0.05) among these antipsychotic drugs.
CONCLUSION:All 7 antipsychotic drugs can improve the life quality of schizophrenia patients. Atypical antipsychotic drugs, especially olazapine and quetiapine, are superior to typical antipsychotic drugs in improving life quality.
