Expression of Raf kinase inhibitor protein and E-cadherin in prostate cancer tissues.
- Author:
Shenxiu LU
1
;
Kuangbiao ZHONG
;
Liyong ZHU
;
Leye HE
Author Information
1. Department of Urology, Third Xiangya Hospital, Central South University, Changsha, China.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
metabolism;
pathology;
Aged;
Aged, 80 and over;
Cadherins;
genetics;
metabolism;
Fluorescent Antibody Technique;
Humans;
Male;
Middle Aged;
Neoplasm Metastasis;
Phosphatidylethanolamine Binding Protein;
genetics;
metabolism;
Prostatic Neoplasms;
metabolism;
pathology
- From:
Journal of Central South University(Medical Sciences)
2009;34(9):892-897
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect the expression of Raf kinase inhibitor protein (RKIP) and epithelial cadherin (E-cadherin) in human prostate cancer tissues, and their correlation.
METHODS:We discussed the relationship between RKIP and E-cadherin and the clinical stage and pathological classification of prostate cancer by immunofluorescence histochemistry staining in the test of expression of RKIP in 26 prostate cancer tissues and 14 BPH tissues, and analyzed the correlation between them.
RESULTS:The expression of RKIP and E-cadherin in prostate cancer tissues was obviously lower than that in the benign prostatic hypertrophy tissues. The expression of RKIP and E-cadherin in the dys-good differentiation group (Gleason 8-10) was significantly lower than that in the good differentiation group(Gleason
CONCLUSION:RKIP and E-cadherin are metastasis suppressor factors, whose decreased expression can increase the invasive capability of prostate cancer and suppress its differentiation. RKIP can suppress the metastasis of prostate cancer by increasing the E-cadherin expression in prostate cancer.
