Association of genetic polymorphism in phenylethanolamine-N-methyl transferase with essential hypertension in Changsha Han people.
- Author:
An CHEN
1
;
Xiaoping CHEN
;
Ruizheng SHI
;
Yijie GUO
;
Lujia CHEN
;
Mingxuan XIE
;
Tianlun YANG
;
Guogang ZHANG
Author Information
1. Department of Cardiovasology, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Base Sequence;
Case-Control Studies;
China;
Female;
Genetic Predisposition to Disease;
genetics;
Humans;
Hypertension;
enzymology;
genetics;
Male;
Middle Aged;
Molecular Sequence Data;
Phenylethanolamine N-Methyltransferase;
genetics;
Polymorphism, Genetic;
Sex Factors
- From:
Journal of Central South University(Medical Sciences)
2009;34(11):1120-1125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the association of phenylethanolamine-N-methyl transferase (PNMT) G-390A genetic polymorphism with risk of essential hypertension (EH) in Changsha Han people.
METHODS:A case-control association study was performed in 400 patients with essential hypertension (EH) and 388 normotensive subjects. PNMT G-390A was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-FRLP).
RESULTS:The genotype frequencies for the -390 GG, GA, and AA were 39.3%,50.0%, and 10.8%, respectively in EH patients, and were 43.6%,45.6%, and 10.8%, in normal subjects. No significant difference in either genotypic frequency (P=0.433) or allele frequency (P=0.378) of PNMT G-390A between EH patients and normals was observed. When by gender, there was significant difference in genotypic frequency (P<0.05) and allele frequency (P=0.046) of G-390A polymorphism between EH patients and normals in the male, but not in the female (P>0.05).
CONCLUSION:PNMT G-390A polymorphism is possibly associated with EH risk in male Chinese Han population in Changsha.
