Protective effect of aminophylline on cerebral injury during cardiopulmonary bypass in infants.
- Author:
Shan PAN
1
;
Guoqiang LIN
;
Haihe JIANG
;
Rimao HUANG
Author Information
1. Department of Thoracic Surgery, Fuzhou Pulmonary Hospital, Fuzhou Fujian 350000,China.
- Publication Type:Journal Article
- MeSH:
Aminophylline;
administration & dosage;
therapeutic use;
Brain Diseases;
etiology;
prevention & control;
Cardiopulmonary Bypass;
adverse effects;
Cardiovascular Surgical Procedures;
Child, Preschool;
Female;
Heart Septal Defects;
drug therapy;
surgery;
Humans;
Infant;
Injections, Intravenous;
Male;
Nerve Growth Factors;
blood;
Neuroprotective Agents;
therapeutic use;
S100 Calcium Binding Protein beta Subunit;
S100 Proteins;
blood
- From:
Journal of Central South University(Medical Sciences)
2009;34(11):1126-1131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effect of aminophylline on cerebral injury induced by cardiopulmonary bypass (CPB) in infants.
METHODS:Forty patients who underwent ventricular septal defect within 3 years old were randomly divided into 2 groups(20 cases in each group).Aminophylline group:aminophylline (5 mg/kg) was injected slowly via the vein after anesthesia and maintained at a dose of 0.5 mg/(kg.h) until the end of CPB.
CONTROL GROUP:aminophylline was replaced by Ringer's lactated solution. Samples were obtained at the beginning of CPB (T(1)),the end of CPB (T(2)),6 h (T(3)) and 24 h (T(4)) after the operation to measure S-100 beta protein, NSE, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and interleukin-10 (IL-10) concentration by ELISA in the 2 groups.
RESULTS:Compared with the time point immediately before CPB, the S-100beta protein,NSE, TNF-alpha, and IL-8 concentration in the 2 groups began to increase with the start of CPB, reached a climax at the end of CPB (T(2)),decreased gradually 6 h after the termination of CPB(T(3)) and could not restore to the level before CPB at T(4)(24 h after the termination of CPB).IL-10 in the 2 groups both increased after the CPB. At T(2) and T(3), S-100beta protein,NSE, TNF-alpha, and IL-8 concentrations were significantly lower than those in the aminophylline group (P<0.05 or P<0.01), while IL-10 was just the opposite.
CONCLUSION:There is cerebral damage induced by CPB. Aminophylline may play a protective role in cerebral injury by modulating the balance between the pro-inflammatory factor and anti-inflammatory factor to reduce the level of S-100beta protein and NSE during CPB and open cardiac surgeries.
