TGF-beta1-800G>A polymorphism and cerebral infarction in Chinese Han population.
- Author:
Yiqun XIE
1
;
Kaimin ZENG
;
Yining WANG
;
Hongwei XU
Author Information
1. Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
- Publication Type:Journal Article
- MeSH:
Case-Control Studies;
Cerebral Infarction;
genetics;
China;
ethnology;
Female;
Gene Frequency;
Genotype;
Humans;
Male;
Polymorphism, Genetic;
genetics;
Polymorphism, Single Nucleotide;
Transforming Growth Factor beta1;
genetics
- From:
Journal of Central South University(Medical Sciences)
2009;34(12):1166-1170
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To investigate the association between transforming growth factor beta1(TGF-beta1)-800G>A polymorphism and cerebral infarction (CI).
METHODS:The genotypes of 247 patients with atherosclerotic cerebral infarction and 167 sex- and age-matched healthy controls were detected by PCR-RFLP, and the frequency distribution of alleles calculated.
RESULTS:TGF-beta1-800G>A polymorphism was found in Han population in Hunan Province, China. The distribution of -800G>A genotypes was consistent with Hardy-Weinberg balance in the CI and healthy control group. There was no significant difference between genotypes and allele frequency of TGF-beta1-800G>A in the CI and control group (P>0.05). Logistic regression analysis suggested that no genotypes could increase or reduce the risk of CI onset (P>0.05).
CONCLUSION:TGF-beta1-800G>A polymorphism is not associated with CI in Han population in Hunan Province.
