Treatment of brain injured rats through transplanting amniotic-derived mesenchymal stem cells in different ways.
- Author:
Gong-ping WANG
1
;
Bo YANG
;
Fang-xia GUAN
;
Ying DU
;
Ke-liang CHANG
;
Lai-jun SONG
;
Xiang HU
;
Guang-wei ZENG
Author Information
1. Department of Neurosurgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052û Department of Tumor, First Affiliated Hospital, Henan University of Science and Technology, Luoyang Henan 471003, China.
- Publication Type:Journal Article
- MeSH:
Amnion;
cytology;
Animals;
Brain Injuries;
therapy;
Female;
Male;
Mesenchymal Stem Cell Transplantation;
methods;
Mesenchymal Stem Cells;
cytology;
physiology;
Nerve Regeneration;
physiology;
Random Allocation;
Rats;
Rats, Wistar
- From:
Journal of Central South University(Medical Sciences)
2008;33(10):926-930
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the behavioral improvement to find the best transplantation approach for treating brain injury through transplanting amniotic-derived mesenchymal stem cells into brain injured rats in different ways.
METHODS:Eighty brain injured Wista rats were randomly divided into a control group with brain injury alone (n=20) and a treatment group(n=60) which were further evenly divided into Group A (transplanted through the vena caudalis), Group B (transplanted through the ventriculus cerebri lateralis), and Group C (transplanted through the injured brain area). Each group was transplanted with amniotic-derived esenchymal stem cells, and their therapeutic efficacy would be evaluated through the neurological severity score (NSS).
RESULTS:Compared with other groups, the behaviors of Group C had markedly improved. There was statistically significant difference in the 2 groups (P<0.05). Compared with the control group, the behaviors of Group A and Group B had marked improvement. There was statistically significant difference in the 3 groups (P<0.05). However, there was no significant difference between Group A and the control group (P>0.05).
CONCLUSION:Transplanting the amniotic-derived mesenchymal stem cells into the injured brain area may be effective for brain injury in rats.
