Association of metabolic syndrome with serum interleukin-10 and high sensitive C reactive protein(hs-CRP) in old men.
- Author:
Ling-xi CHEN
1
;
Sai-dan ZHANG
;
Li-li ZHU
;
Ming SUN
Author Information
1. Department of Cardiology, Xiangya Hospital, Central South University, Changsha 410008, China.
- Publication Type:Journal Article
- MeSH:
Aged;
C-Reactive Protein;
metabolism;
Enzyme-Linked Immunosorbent Assay;
Humans;
Inflammation;
complications;
Interleukin-10;
blood;
Male;
Metabolic Syndrome;
blood;
complications;
Middle Aged
- From:
Journal of Central South University(Medical Sciences)
2008;33(10):970-974
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association of metabolic syndrome(MS) with serum interleukin-10 (IL-10) and high sensitive C reactive protein(hs-CRP) in old men with MS.
METHODS:Seventy patients with MS and 30 age-matched controls were enrolled. Blood pressure, waist circumference(WC), weight, height, body mass index(BMI), lipid-profile, fasting plasma glucose(FPG), fasting plasma insulin (FINS), homeostasis model assessment of insulin resistance(HOMA-IR),the serum IL-10, and hs-CRP levels were measured. The concentration of serum IL-10 was measured by enzyme linked immunosorbent assay (ELISA), and serum hs-CRP level by the latex-enhanced immuno- turbidimetric assay.
RESULTS:Compared with the control group, the serum IL-10 level in the MS group was significantly lower (P<0.05), and the concentration of hs-CRP was obviously higher (P<0.05). Using Pearson's correlation analysis, the serum IL-10 level was negatively related with HOMA-IR(r=-0.684,P=0.000)and FINS(r=-0.742,P=0.000); hs-CRP was positively related with BMI(r=0.372,P=0.002), HOMA-IR(r=0.276,P=0.021)and FINS(r=0.312,P=0.008)in the MS group. Stepwise regression analysis suggested that FINS might be the influencing factors of IL-10; BMI and FINS might be the influencing factors of hs-CRP in patients with MS.
CONCLUSION:In old male patients with MS, the concentration of serum IL-10 decreases, and the serum hs-CRP level increases obviously. This suggests chronic inflammation.
