Expression and significance of human beta-defensin in recurrent nasal polyps.
- Author:
Huo-Wang LIU
1
;
Guang-Xiang HE
;
Hong SUN
Author Information
1. Department of Otorhinolaryngology-Head & Neck Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Case-Control Studies;
Female;
Humans;
Male;
Middle Aged;
Nasal Mucosa;
metabolism;
Nasal Polyps;
metabolism;
RNA, Messenger;
genetics;
metabolism;
Recurrence;
Reverse Transcriptase Polymerase Chain Reaction;
Young Adult;
beta-Defensins;
genetics;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2008;33(12):1119-1122
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the expression of human beta-defensin-1 (hBD-1) and human beta-defensin-2 (hBD-2) in recurrent nasal polyps, and to investigate the role of beta-defensin in the recurrent nasal polyps.
METHODS:Tissues of nasal polyps was obtained from 10 patients with nasal polyps undergoing endoscopic sinus surgery, recurrent nasal polyps from 10 patients 6 months after surgery, nasal mucosa from 10 recovered patients with nasal polyps postoperatively and,10 control subjects. hBD-1 mRNA and hBD-2 mRNA levels of tissue specimens in all groups were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTS:There was no significant difference in hBD-1 mRNA level between the 4 groups (P>0.05). Expression of hBD-2 mRNA was detected in patients with nasal polyps and recurrent nasal polyps, but rare in the recovered patients and the control subjects.
CONCLUSION:hBD-1 is a constitutive expression and hBD-2 is an induced expression. beta-Defensin may play an important role in forming the nasal polyps.
