Biochemical markers of age-related changes in bones turnover and bone mineral density in healthy Chinese men.
- Author:
Yue-xia JIANG
1
;
Si-yuan TANG
;
Xian-ping WU
;
Ling-feng YANG
;
Er-yuan LIAO
Author Information
1. School of Nursing, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Age Factors;
Aged;
Aged, 80 and over;
Alkaline Phosphatase;
metabolism;
Biomarkers;
Bone Density;
Bone and Bones;
metabolism;
Collagen Type I;
metabolism;
Humans;
Male;
Middle Aged;
Osteoporosis;
prevention & control;
Peptides;
metabolism
- From:
Journal of Central South University(Medical Sciences)
2008;33(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the relationship between bone alkaline phosphatase (BAP) and cross-linked N-telopeptides of type I collegen(NTX) and bone mineral density in healthy men aged 20-80.
METHODS:BAP and NTX of 389 healthy men were measured by ELISA. BMD at the lumbar spine and the hip as measured by dual energy X-ray absorptiometry. The correlation of bone biochemical markers with age and BMD fit 10 regression models.
RESULTS:BAP and NTX negatively correlated with age. The cubic regression model was better with age-related changes of bone biochemical markers as compared with the other regression models and the coefficients of determination of fitting curve were 0.013-0.029 (P< 0.05). The value of bone biochemical markers as the highest during 20-29 age groups, then they decreased to a nadir level in the 50-59 years age. After 60 years, bone formation markers remained stable; however resorption marker increased slightly. After adjustment for age, weight, height, BMI, and smoking, bone biochemical markers were negatively correlated with most sites of BMD.
CONCLUSION:BAP and NTX may be relatively sensitive and specific markers to evaluate age-related changes of bone turnover. It may benefit the prevention of osteoporosis by monitoring the level of BAP and NTX.
