Clinical characteristics and prognostic factors in 73 patients with peripheral T cell lymphoma.
- Author:
Xiao-chun HUANG
1
;
Xiao-lin LI
;
Ran-xin HUANG
;
Xiang-shu JIN
Author Information
1. Department of Hematology, Xiangya Hospital, Central South University, Changsha, China. zuzu2001@163.com
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
CA-125 Antigen;
blood;
Female;
Fibrin Fibrinogen Degradation Products;
metabolism;
Humans;
Lymphoma, T-Cell, Peripheral;
diagnosis;
pathology;
therapy;
Male;
Middle Aged;
Prognosis;
Retrospective Studies;
Survival Rate
- From:
Journal of Central South University(Medical Sciences)
2008;33(2):151-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical features,therapy and prognosis of patients with peripheral T cell lymphoma(PTCL), and to find out the prognostic factors of the disease.
METHODS:The clinical data of 73 patients with PTCL were reviewed.The median pre-treatment disease course was 3 months.Fifty-five patients were males, and 18 were females, with the median age of 42 years.Five patients received the combined chemo-radio therapy, 65 received chemotherapy alone, and the other 3 patients were treated with auto hematopoietic stem cell transplantation (HSCT).
RESULTS:Of all the patients, the overall 3 -year and 5-year survival rates were 38% (28 /73) and 22% ( 16 /73) respectively.The survival rates decreased with the progression of the Ann Arbor stages.The survival rate of the patients with B symptom (fever, night sweat, and weight loss) or the international prognostic factors index ( IPI)>2 was lower than those of the patients without B symptom or IPI<2.The patients with the increased CA125 or D-dimer lever had the worst curative effect.
CONCLUSION:Peripheral T cell lymphoma is highly aggressive with poor prognosis.The clinical features,Ann Arbor staging, IPI and B symptom are important prognostic factors.CA125 and D-dimer may be also important prognostic factors.
